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Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
From feeds.nature Tobias Eckle et al. describe a new regulatory circuit in the heart by which adenosine receptor signaling controls expression of the circadian protein Per2, which stabilizes the transcription factor Hif-1I+-, promotes glycolytic metabolism and has cardioprotective effects. Exposing mice to intense light was able to stabilize Per2 in the heart and reduce cardiac injury after myocardial ischemia.
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